Because of a lapse in government funding, the information on this website may not be up to date, transactions
submitted via the website may not be processed, and the agency may not be able to respond to inquiries until
appropriations are enacted.
The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please
visit cc.nih.gov.
Updates regarding government operating status and resumption of normal operations can be found at OPM.gov.
Ante la falta de fondos del gobierno federal, no se actualizará este sitio web y la organización no responderá
a transacciones ni consultas hasta que se aprueben los fondos.
El Centro Clínico de los Institutos Nacionales de la Salud (el hospital de investigación) permanecerá abierto.
Consulte cc.nih.gov (en
inglés).
Infórmese sobre el funcionamiento del gobierno federal y el reinicio de las actividades en
opm.gov.
E1 is the replication initiator protein. The replication origin contains specific consensus motifs for the E1 and E2 proteins, which initially cooperatively bind to the origin through sequence specific DNA binding domains. Next, E1 converts to a double hexameric helicase to unwind the viral DNA bidirectionally. The E1 protein shuttles between the nucleus and cytoplasm and this is regulated by phosphorylation of an N-terminal shuttling domain.
E1 proteins are approximately 600 amino acids long and are encoded by all papillomaviruses. They consist of an N-terminal shuttling domain, an origin-specific DNA binding domain, an oligomerization region and a helicase domain.
